Table 9.
Performance of cut-off values for AmtRNA, AwMA, and AmtDNA (OD 405nm).
| Cutpoint (95% BCI) | Sensitivity (95% ECI) | Specificity (95% ECI) | PPV (95% ECI) | NPV (95% ECI) | AUC (95% ECI) | ||
|---|---|---|---|---|---|---|---|
| AmtRNA | IgG | 0.30 (0.11–0.54) | 0.49 (0.38–0.60) | 0.90 (0.73–0.98) | 0.93 (0.82–0.99) | 0.38 (0.27–0.50) | 0.72 (0.62–0.82) |
| IgM | 0.52 (0.24–0.64) | 0.38 (0.28–0.49) | 0.87 (0.69–0.96) | 0.89 (0.75–0.97) | 0.33 (0.23–0.44) | 0.62 (0.51–0.72) | |
| AwMA | IgG | 0.30 (0.12–0.44) | 0.36 (0.26–0.47) | 0.80 (0.61–0.92) | 0.84 (0.68–0.94) | 0.30 (0.21–0.42) | 0.57 (0.45–0.69) |
| IgM | 0.68 (0.19–1.37) | 0.24 (0.16–0.35) | 0.87 (0.69–0.96) | 0.84 (0.64–0.96) | 0.29 (0.20–0.39) | 0.48 (0.37–0.60) | |
| AmtDNA | IgG | 0.44 (0.22–1.25) | 0.35 (0.25–0.46) | 0.77 (0.58–0.90) | 0.81 (0.65–0.92) | 0.29 (0.19–0.40) | 0.51 (0.40–0.62) |
| IgM | 0.36 (0.24–0.57) | 0.51 (0.40–0.62) | 0.83 (0.65–0.94) | 0.90 (0.78–0.97) | 0.37 (0.26–0.50) | 0.65 (0.55–0.75) |
Values in bold have an AUC significantly different than 50%.
AmtDNA, anti-mitochondrial DNA antibodies. AmtRNA, anti-mitochondrial RNA antibodies. AUC, area under the curve. AwMA, anti-whole mitochondria antibodies. BCI, Bootstrap Confidence Interval. ECI, Exact Confidence Interval. NPV, Negative Predictive Value. OD, optical density. PPV, Positive Predictive Value. Data in bold are statistically significant (p < 0.05)