Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 10;13:460. doi: 10.3389/fnins.2019.00460

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Weidner, Lardenoije, Eijssen, Mogavero, De Groodt, Popp, Palme, Förstner, Strekalova, Steinbusch, Schmitt-Böhrer, Glennon, Waider, van den Hove and Lesch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Overlap between differentially expressed genes (DEGs) and differentially methylated loci (DMLs) in the amygdala of mice that were exposed to maternal separation (MS) and are offspring of tryptophan hydroxylase 2-deficient (Tph2^+/-) parents. For statistical analysis of RNA expression and DNA methylation, contrasts were calculated for Tph2^∗MS interactions GE1 [(Tph2^+/- MS-Tph2^+/- C)-(Tph2^+/+ MS-Tph2^+/+ C)] and GE2 [(Tph2^-/- MS-Tph2^-/- C)-(Tph2^+/+ MS-Tph2^+/+ C)]. Per group 8 samples (total 48 samples were sequenced for either analysis). For DNA methylation data, pre-analysis quality control revealed two outlier samples, both of the Tph2^-/- MS condition, which were excluded from analysis. Genes of either analysis were determined differential if they showed a nominal p < 0.01 and lg2FC > | 0.2|. Fars2, phenylalanine-tRNA synthetase 2 (mitochondrial); Nsun2, NOL1/NOP2/Sun domain family member 2; Cck, cholecystokinin; Xkr4, X-linked Kx blood group related 4; 5830473C10Rik, RIKEN cDNA 5830473C10 gene; Gm10801, predicted gene 10801; A830073O21Rik, RIKEN cDNA A830073O21 gene; Gm26596, predicted gene 26596; Stx1a, syntaxin 1A (brain); Stom, stomatin; Gm13179, predicted gene 13179.