The RFS of 4.1R in BC. (A) High mRNA level of 4.1R was associated with longer RFS in all BC patients. (B, C) High mRNA level of 4.1R was associated with longer RFS both in ER-positive and ER-negative BC patients. (D–G) High mRNA level of 4.1R was associated with longer RFS in HER2+, luminal B, and basal-like, but not in luminal B BC patients. (H, I) High mRNA level of 4.1G was associated with longer RFS in Her-2 negative, but not in Her-2-positive subtype BC patients.