The relapse-free survival (RFS) of 4.1G in BC. (A) High mRNA level of 4.1G was associated with longer RFS in all BC patients. (B–E) High mRNA level of 4.1G was associated with longer RFS in ER-positive, luminal A, luminal B, and LN-negative subtype BC patients. (F–J) High mRNA level of 4.1G was not associated with longer RFS in ER-negative, LN-positive, basal-like, HER2+, or Her-2 negative subtype BC patients. (K) High mRNA level of 4.1G was associated with worse RFS in Her-2-positive subtype BC patients. (L) High mRNA level of 4.1G was associated with longer RFS in luminal B subtype BC patients with Tamoxifen treatment.