Table 1.
Brine shrimp lethality assay and antitumor activity of synthesized dexibuprofen amides (4a–j)
| Compounds | Brine shrimp lethality LD50 (µg/mL) | Antitumor activity | |
|---|---|---|---|
| Average number of tumors ± SE | Inhibition of tumors (%) | ||
| 4a | 356.31±21.4 | 2.15±0.22 | 34.66 |
| 4b | 263.25±16.8 | 1.76±0.20 | 46.51 |
| 4c | 543.46±13.7 | 2.13±0.17 | 35.26 |
| 4d | 390.57±11.3 | 1.02±0.15 | 69 |
| 4e | 270.53±12.3 | 0.0±0.0 | 100 |
| 4f | 412.45±11.3 | 2.72±0.23 | 17.33 |
| 4g | 359.55±9.4 | 0.0±0.0 | 100 |
| 4h | 541.64±13.5 | ND | ND |
| 4i | 434.44±11.6 | ND | ND |
| 4j | 289.67±12.54 | 1.34±0.14 | 59.28 |
| Potassium dichromate | 0.89±0.01 ND | ND | ND |
| Negative control | 1.34±0.14 | 59.28 | |
Notes: Data is based on mean value of three replicates of each for 1,000, 100 and 10 µg/mL concentrations against brine shrimps (in vitro); compound dilutions were prepared with DMSO. Data represents mean value of 15 replicates.
Abbreviations: SE, standard error; DMSO, dimethyl sulfoxide; ND, not determined.