Table 6.

Docking energy evaluation of synthesized amides (4a–j) against BRCA1

Compounds	Binding energy (Kcal/mol)	Ligand efficacy	Intermolecular energy (Kcal/mol)	Torsional energy (Kcal/mol)	Unbound energy (Kcal/mol)
4a	−5.67	−0.26	−7.46	1.79	−4.43
4b	−4.65	−0.21	−7.04	2.39	−3.19
4c	−4.41	−0.21	−6.20	1.79	−5.07
4d	−6.24	−0.30	−8.03	1.19	−3.92
4e	−6.39	−0.28	−7.58	1.19	−3.38
4f	−4.61	−0.22	−6.40	1.79	−3.51
4g	−6.34	−0.29	−7.54	1.19	−0.97
4h	−5.21	−0.19	−8.49	3.28	−3.24
4i	−4.44	−0.23	−6.53	2.09	−4.08
4j	−4.61	−0.22	−6.40	1.79	−2.95