Table 2.
Pattern matrix of PCA results for cerebellar lobar values of Cortical Thickness (CT) of 94 subjects [66 patients with ALS and 24 healthy controls (HCs)].
| Rotated cluster loadings | |||||
|---|---|---|---|---|---|
| Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | KMO value | |
| CTz Lobule IX | 0.882 | 0.100 | -0.165 | 0.181 | 0.752 |
| CTz Lobule VIIIB | 0.854 | 0.210 | -0.246 | 0.398 | 0.746 |
| CTz Lobule VIIIA | 0.704 | 0.672 | -0.120 | 0.220 | 0.725 |
| CTz Lobule VIIB | 0.255 | 0.894 | 0.004 | -0.049 | 0.595 |
| CTz Lobule CRUSII | 0.053 | 0.840 | -0.472 | 0.003 | 0.645 |
| CTz Lobule VI | 0.113 | 0.112 | -0.858 | 0.144 | 0.822 |
| CTz Lobule CRUS I | 0.050 | 0.404 | -0.830 | 0.048 | 0.693 |
| CTz Lobule V | 0.509 | -0.160 | -0.767 | 0.373 | 0.763 |
| CTz Lobule IV | 0.472 | -0.184 | -0.745 | 0.490 | 0.728 |
| CTz Lobule I&II | 0.221 | -0.083 | -0.114 | 0.882 | 0.685 |
| CTz Lobule III | 0.130 | -0.195 | -0.213 | 0.861 | 0.612 |
| CTz Lobule X | 0.247 | 0.138 | -0.110 | 0.454 | 0.700 |
| Eigenvalues | 3.929 | 2.295 | 1.757 | 1.122 | |
| % of variance | 32.74 | 19.13 | 14.64 | 9.35 | |
The loading values in bold indicate the elements that contribute the greatest variability to PCA clusters. ALScn, ALS patients with a cognitive and behavioral normal profile; ALSimp, ALS patients fulfilling Strong criteria for behavioral and/or cognitive impairment; C9+ALS, ALS patients with C9orf72 repeat expansions; and HC, Healthy Controls.