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. 2019 May 10;13:48. doi: 10.3389/fnana.2019.00048

Figure 7.

Figure 7

Catecholamine and cholinergic nuclei of the dorsal raphe/PAG. The dorsal raphe nucleus extends from the rostral pons up to the midbrain within and around the ventromedial and ventrolateral PAG. In fact, at this level, three sub-regions of the dorsal raphe intermingling with PAG are identified, namely, dorsal (DRD), ventral (DRV) and lateral (DRL; Steinbusch et al., 1981; Baker et al., 1990, 1991). While 5-HT neurons are scattered throughout all the dorsal raphe, the ventromedial and mostly the ventrolateral PAG (VLPAG) hosts a mixed neuronal population, among which catecholamine and cholinergic neurons prevail at large. This is the case of the NE nucleus epicoeruleus corresponding to the rostral and dorsal extent of the LC complex. Similarly, DA neurons of the A10dc nucleus, as well as cholinergic neurons of the Ch6 (LDTg) intermingle in the DRL/VLPAG with their rostral extent.