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. 2018 Nov 16;1(1):40–50. doi: 10.1096/fba.1021

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© 2018 The Authors.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Overexpression of TRPC1 rescues the effect of Tunicamycin (Tu) and Brefeldin A (BFA). (A,B), Respective western blots showing the expression of various endoplasmic reticulum (ER) stress markers in TRPC1 overexpressed cells pretreated with Tu and BFA. C, Representative trace showing Tg‐evoked Ca²⁺ entry and Ca²⁺‐evoked [Ca²⁺]_i changes in various conditions as labeled in the figure. D, Bar diagram of the fluorescence ratio (340/380) from an average of 40‐60 cells. E, Bar diagram showing the cell survival of the cells pretreated with 10 μM Tu or BFA, respectively, for 24 h in TRPC1 overexpressed human salivary gland (HSG) cells. F, Schematic model showing the role of TRPC1 channels in ER stress and salivary gland cell death. Graphs are mean ± SEM, significance: *, P < 0.05; **, P < 0.001.