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Schematic depicting proposed phosphate- and STC1-related interactions involved in hMSC depolarization during OS differentiation. Vmem depol may alter Na+ and Pi transport across the cell membrane through the Na+-dependent Pi cotransporter SLC20A1. Pi levels, in turn, may alter intracellular STC1 expression. STC1 regulates the expression of OS genes such as ALPL and IBSP and also critically regulates late-stage mineralization. Vmem depol, membrane potential depolarization.
