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Schematic diagram of simvastatin induced pathways and gene network during rat periodontitis model. Simvastatin directly regulates by IGF‐1, FGF7, Wnt/β‐catenin, and IL‐1 receptor‐like (1IL1rl1) that may play decisive roles in (1) activating periodontal ligament/fibroblast growth and homeostasis, (2) induction of alveolar bone repair and regeneration, and (3) immune response and repression of periodontitis.
