Table 3.
Strength of the Zoledronic Acid + Rowing Effect (Rowing‐Only Group as Reference) in Models Adjusting for Baseline Values and Clinical/Demographic Factors
| Cortical bone volume (mm3) | Cortical Thickness Index (mm) | Buckling ratio (BRe) | ||||
|---|---|---|---|---|---|---|
| Proximal tibia | β ± SE | p | β ± SE | p | β ± SE | p |
| Fully adjusted, all participants (n = 20) | 345 (109) a | 0.006 | 0.012 (0.004) | 0.013 | 4.51 (1.73) | 0.019 |
| Fully adjusted, chronic SCI only (n = 18) | 410 (100) a | 0.001 | 0.014 (0.005) | 0.007 | 5.20 (1.80) | 0.012 |
| Fully adjusted, males only, no statin users (n = 16) | 404 (91) a | 0.001 | 0.017 (0.004) | 0.001 | 5.52 (1.35) b | 0.001 |
| Distal femur | ||||||
| Fully adjusted, all participants (n = 20) | 471 (225) c | 0.05 | 0.016 (0.006) c | 0.009 | 5.47 (2.04) d | 0.015 |
| Fully adjusted, chronic SCI only (n = 18) | 490 (256) c | 0.076 | 0.017 (0.006) c | 0.015 | 6.20 (2.10) d | 0.009 |
| Fully adjusted, males only, no statin users (n = 16) | 400 (256) c | 0.14 | 0.014 (0.006) c | 0.04 | 4.94 (2.28) d | 0.05 |
All models are adjusted for baseline bone geometry values.
SCI = Spinal cord injury.
a
Adjusting for baseline leg lean mass (p = 0.007 to 0.04).
b
Adjusting for total rowing work (p = 0.05).
c
Adjusting for age injury (p = 0.000 to 0.003), baseline leg lean mass (p = 0.000 to 0.001), baseline 25‐OH vitamin D level (p = 0.01 to 0.03).
d
Adjusting for age at injury (p = 0.001 to 0.02), baseline leg lean mass (p = 0.000 to 0.01).eBR has no units; beta coefficients are multiplied by 1000 here for ease of interpretation.