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. 2019 Apr 30;10:461. doi: 10.3389/fphar.2019.00461

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Copyright © 2019 Bresciani, Saletti, Squillace, Rizzi, Molteni, Meanti, Omeljaniuk, Biagini, Gori, Locatelli and Torsello.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNA-218 levels affect lipin-1 and GLUT-4 mRNA expression. Fully differentiated 3T3-L1 cells treated with LPV:RTV (12 μM:3 μM) (PIs) for 48 h or with vehicle alone, were transfected with: (A) scrambled miRNA or miRNA-let-7 inhibitor; (B,C) miRNA-218 inhibitor or miRNA-218 mimic or with scrambled miRNA. mRNA levels of HMGA-2 (A) lipin-1 (B) and GLUT-4 (C) were determined by real-time PCR 48 h after the transfection. Values are the mean ± SEM of at least 18 determination obtained in three independent experiments. ^∗p < 0.05, ^∗∗p < 0.01 and ^∗∗∗p < 0.001 vs. control (PIs+ scrambled miRNA).