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. 2019 May 14;12(5):890–905. doi: 10.1016/j.stemcr.2019.04.011

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Interactions between Dorsally and Ventrally Derived Oligodendroglia in the FFOs

(A) A schematic procedure for fusing the VFOs and DFOs that were respectively derived from isogenic OLIG2-GFP hiPSC reporter line and ND2.0 hiPSC line that do not have any reporter fluorescence.

(B and C) Representatives (B) and quantification (C) (n = 4 organoids) showing that ventrally derived OLIG2⁺ cells (GFP⁺) are outnumbered by dorsally derived OLIG2⁺ cells (GFP-negative) at 1 week after fusion (week 10) to 6 weeks after fusion (week 15). Student's t test: ^∗∗∗p < 0.001. Scale bar, 100 μm.

(D and E) Quantification (D) and representatives (E) showing MBP⁺ cells with a ventral (GFP⁺) or dorsal (GFP-negative) origin (n = 4 organoids). Student's t test: ^∗∗∗p < 0.001. Scale bars, 50 μm.