Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
TR-FRET and Docking affinities for THQ analogs bound to BRD2 bromodomains
| Model | BD1 pIC50 |
BD2 pIC50 |
TR- FRET BD2/BD1 |
Dock BD1 pKd |
Dock BD2 pKd |
Dock BD2/BD1 |
|---|---|---|---|---|---|---|
| 5 | 5.69 | 6.21 | 3.3 | 7.24 | 7.56 | 2.1 |
| 6 | 5.75 | 6.08 | 2.1 | 7.46 | 7.65 | 1.5 |
| 7 | 5.85 | 5.85 | 1.0 | 7.40 | 7.56 | 1.4 |
