. Author manuscript; available in PMC: 2019 Nov 1.

Published in final edited form as: Neurobiol Learn Mem. 2018 Aug 9;155:239–248. doi: 10.1016/j.nlm.2018.08.009

Table 2: Chromatin remodeling genes show the highest enrichment out of the differentially methylated genes identified.

PANTHER (GO-Ontology) enrichment tool was used to identify over represented functional gene categories in the 462 differentially methylated genes for which methylation was modulated by nicotine and reversed by choline. Short list of the most enriched Go Ontology gene categories, Full list can be found in Table 2–1 “Full PANTHER analysis”.

Go term	Total genes in category	Genes in current study	Fold enrichment	P value ^*
chromatin remodeling (G0:0006338)	122	14	5.67	2.70E–03
positive regulation of neuron projection development (G0:0010976)	312	23	3.64	1.53E–03
positive regulation of nervous system development (G0:0051962)	566	36	3.14	2.38E–05
positive regulation of neurogenesis(G0:0050769)	499	29	2.87	5.33E–03
Cell migration (G0:0045666)	744	43	2.85	1.12E–05

Bonferroni corrected