Table 3. Incidence and expression of thrombophilia states.
| Tests | MINOCA | MICAD | p |
|---|---|---|---|
| Median (25th and 75th percentiles) or % ( n ) | |||
| Congenital thrombophilia | |||
| Antithrombin III units | 101 (72, 134) | 100 (82, 122) | 0.86 |
| Antithrombin deficiency | 8% 2 | 0 | 0.22 |
| Protein C units | 121 (65, 293) | 116 (78, 189) | 0.74 |
| Protein C deficiency | 0 | 0 | – |
| Protein S units | 111 (49, 142) | 104 (67, 150) | 0.18 |
| Protein S deficiency | 4% 1 | 0 | 0.47 |
| Factor V Leiden | 0 | 4% 1 | – |
| Prothrombin gene mutation | 8% 2 | 4% 1 | 0.59 |
| Acquired thrombophilia | |||
| Anticardiolipin antibody (GPL a units) | 1.5 (1, 4) | 2.3 (1, 18) | 0.38 |
| Antiphospholipid antibody syndrome | 0 | 0 | – |
| Presence of lupus anticoagulant | 0 | 0 | – |
| Factor VIII (IU/dL) | 168 (61, 301) | 159 (78, 229) | 0.72 |
| Above normal (>180) | 44% 11 | 36% 9 | 0.42 |
| von Willebrand factor antigen (IU/dL) | 151 (60, 299) | 147 (57, 274) | 0.88 |
| Above normal (>240) | 12% 3 | 4% 1 | 0.17 |
| Coagulation markers | |||
| Fibrinogen units | 3.7 (2.2, 5.4) | 3.8 (2.1, 5.7) | 0.53 |
| Above normal (>4.0) | 44% 11 | 40% 10 | 0.58 |
| D-dimer units | 0.6 (0.1, 1.9) | 0.4 (0.2, 0.9) | 0.47 |
| Above normal (>0.5) | 44% 11 | 36% 9 | 0.41 |
Abbreviations: dRVVT, dilute Russell's viper venom time; MICAD, myocardial infarction with coronary artery disease; MINOCA, myocardial infarction with nonobstructive coronary arteries.
Note: Data expressed as either median (25th and 75th percentiles) or frequencies; p < 0.05 considered significant.
a
GPL denotes IgG isotype.