Table 1. Impact of the DOAC-Stop® adsorbent treatment on common thrombophilia screening tests.
| Apixaban | Dabigatran | Edoxaban | Rivaroxaban | Controls | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 80 ng/mL (10–316) | 73.5 ng/mL (2–406) | 136.5 ng/mL (21–354) | 76.5 ng/mL (7–456) | |||||||
| Before DOAC-Stop® | After DOAC-Stop® | Before DOAC-Stop® | After DOAC-Stop® | Before DOAC-Stop® | After DOAC-Stop® | Before DOAC-Stop® | After DOAC-Stop® | Before DOAC-Stop® | After DOAC-Stop® | |
| Antithrombin (%) | 95.7 | 98.6 | 99.5 | 97.2 | 95.6 | 101.3 | 98.7 | 100.3 | 89.8 | 91.4 |
| p = 0.003 ( n = 26) a | p = 0.09 ( n = 30) | p = 0.01 ( n = 10) a | p = 0.05 ( n = 27) | p = 0.14 ( n = 19) | ||||||
| Free protein S (%) | 104.5 | 101.7 | 99.58 | 97.26 | 99.3 | 99.8 | 101 | 100.2 | 89.2 | 88.3 |
| p = 0.08 ( n = 24) | p = 0.005 ( n = 31) a | p = 0.71 ( n = 10) | p = 0.48 ( n = 25) | p = 0.48 ( n = 19) | ||||||
| Protein C (%) | 105 | 104.9 | 104.8 | 104.7 | 122.7 | 123.2 | 121.0 | 122.5 | 98.5 | 100.8 |
| p = 0.87 ( n = 24) | p = 0.96 ( n = 32) | p = 0.86 ( n = 10) | p = 0.11 ( n = 25) | p = 0.28 ( n = 19) | ||||||
| APC-R | 4.0 | 4.3 | 6.6 | 4.6 | 4.5 | 4.2 | 4.1 | 4.1 | 3.6 | 3.5 |
| p = 0.02 ( n = 20) a | p < 0.0001 ( n = 30) a | p = 0.001 ( n = 10) a | p = 0.98 ( n = 26) | p = 0.22 ( n = 19) | ||||||
| PTT-LA (s) | 42.8 | 38.1 | 55.3 | 37.5 | 38.3 | 34.4 | 42.1 | 35.1 | 36.2 | 36.1 |
| p = 0.0007 ( n = 26) a | p < 0.0001 ( n = 27) a | p = 0.02 ( n = 8) a | p < 0.0001 ( n = 31) a | p = 0.84 ( n = 19) | ||||||
| dRVVT screen (s) | 55.5 | 40.6 | 80.2 | 42.1 | 59.3 | 37.7 | 77.0 | 40.9 | 37.7 | 38.1 |
| p < 0.0001 ( n = 27) a | p < 0.0001 ( n = 31) a | p = 0.04 ( n = 8) a | p < 0.0001 ( n = 31) a | p = 0.43 ( n = 18) | ||||||
| dRVVT confirm (s) | 49.90 | 36.8 | 61.4 | 38.0 | 51.5 | 36.2 | 52.3 | 36.8 | 37.4 | 36.6 |
| p < 0.0001 ( n = 27) a | p < 0.0001 ( n = 29) a | p = 0.04 ( n = 8) a | p < 0.0001 ( n = 31) a | p = 0.09 ( n = 20) | ||||||
| dRVVT ratio | 1.1 | 1.1 | 1.2 | 1.1 | 1.1 | 1.1 | 1.4 | 1.1 | 1.0 | 1.1 |
| p = 0.05 ( n = 27) | p = 0.0005 ( n = 27) a | p = 0.08 ( n = 8) | p < 0.0001 ( n = 31) a | p = 0.07 ( n = 18) | ||||||
Abbreviations: APC-R, activated protein-C resistance; dRVVT, dilute Russell's viper venom time.
Notes: The minimal, median, and maximal DOAC concentration is indicated in the first line of the table. The mean (and 95% confidence interval) of each parameter is presented before and after the DOAC-Stop® treatment.
a
p -Value <0.05.