Fig. 1.

Schematic representation of the primary structure of human plasminogen. The catalytic triad (His603, Asp646, and Ser741) within the protease domain, the activation site (Arg561–Val562), and the 24 disulfide bridges, as well as the signal peptide are indicated. NTP N-terminal peptide; K1–K5 kringles 1–5. (Adapted from Schaller and Gerber. 100 )