Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic illustration of pHLIP’s interaction with lipid bilayers at neutral and acidic pH. State I refers to the free peptide conformation at high pH. State II describes the adsorption of the unstructured peptide on the membrane surface. At state III, acidification allows the protonation of Asp residues with increased hydrophobicity and results in the formation of a transmembrane α-helix. Reprinted with permission from ref 283. Copyright 2010 National Academy of Sciences.
