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. Author manuscript; available in PMC: 2019 May 17.
Published in final edited form as: Cell. 2012 Oct 26;151(3):473–475. doi: 10.1016/j.cell.2012.10.016

Figure 1. TLR11-Mediated Innate Immunity to Salmonella Typhi in the Mouse Intestine.

Figure 1

TLR11 is expressed by small intestinal epithelial cells and by mononuclear phagocytes in the lamina propria. Mathur et al. (2012) report that TLR11 recognition of the Salmonella Typhi flagellin protein enhances epithelial resistance to bacterial invasion and promotes cytokine production by mononuclear cells to enhance systemic resistance to bacterial dissemination. This may help to account for the specificity of S. Typhi for humans, who lack TLR11 expression.