Table 2:
Risk factors for aggressive prostate cancer
| Unadjusted | Adjusteda | |||||
|---|---|---|---|---|---|---|
| Low Gleason |
High Gleason |
OR (95% CI) | P value |
OR (95% CI) | P value |
|
| N (%) | 104 (68%) | 49 (32%) | - | - | - | - |
| Age, median (range)b | 61 (44 – 80) | 63 (41 – 76) | 1.55 (0.95 – 2.53)a | 0.081 | 1.11 (0.55 – 2.24) | 0.772 |
| BMI | 0.740 | 0.682 | ||||
| Underweight/Normal | 26 (70) | 11 (30) | 1.00 | 1.00 | ||
| Overweight/Obese | 70 (67) | 34 (33) | 1.15 (0.51 – 2.59) | 1.25 (0.43 – 3.62) | ||
| Race | ||||||
| AA | 43 (81) | 10 (19) | 1.00 | 1.00 | ||
| HW | 29 (58) | 21 (42) | 3.11 (1.28 – 7.57) | 0.012 | 3.95 (1.21 – 12.92) | 0.023 |
| NHW | 32 (64) | 18 (36) | 2.42 (0.99 – 5.94) | 0.054 | 4.29 (1.04 – 17.71) | 0.044 |
| Biomarker | ||||||
| AR (7 or less) | 37 (73) | 12 (27) | 1.00 | 1.00 | ||
| AR (8) | 66 (66) | 35 (34) | 1.36 (0.65 – 2.86) | 0.415 | 3.06 (0.93 – 10.12) | 0.066 |
| RON (7 or less) | 30 (71) | 12 (29) | 1.00 | 1.00 | ||
| RON (8) | 69 (66) | 35 (34) | 1.27 (0.58 – 2.78) | 0.552 | 1.83 (0.53 – 6.31) | 0.338 |
| FLIP (7 or less) | 22 (76) | 7 (24) | 1.00 | 1.00 | ||
| FLIP (8) | 58 (66) | 30 (34) | 1.63 (0.62 – 4.24) | 0.320 | 1.04 (0.32 – 3.4) | 0.948 |
| SP1 (7 or less) | 9 (69) | 4 (31) | 1.00 | 1.00 | ||
| SP1 (8) | 92 (68) | 43 (32) | 1.05 (0.31 – 3.61) | 0.936 | 0.52 (.09 – 3.03) | 0.463 |
| SP3 (7 or less) | 7 (78) | 2 (22) | 1.00 | 1.00 | ||
| SP3 (8) | 96 (68) | 46 (32) | 1.68 (0.33 – 8.39) | 0.529 | 3.61 (0.35 – 37.1) | 0.281 |
| PSA (<4) | 24 (80) | 6 (20) | 1.00 | 1.00 | ||
| PSA (≥4) | 77 (65) | 41 (35) | 2.13 (0.81 – 5.63) | 0.121 | 3.93 (1.06 – 14.6) | 0.041 |
a
model includes data from 104 patients with complete data on all variables
b
for interval of 10 years