Table 3.
Postoperative Thrombotic/Thromboembolic Events after 3F-PCC usage
| Event | Diagnostic Modifier | Time-to- Event (POD) |
Operation | 3F-PCC (IU/kg) |
rFVIIa (mcg/kg) |
|---|---|---|---|---|---|
| CVA | Ischemic - R Frontoparietal cortex – CT Brain without contrast | 1 | TAA, AVR, Aortic Root Repair | 33.6 | 44.8 |
| CVA | Ischemic – R MCA territory – CT Brain Angio | 25 | BIVAD/VA ECMO | 10.8 | 0 |
| CVA | Ischemic – Diffuse hypodensities within cerebral cortex – CT Brain without contrast | 4 | BIVAD | 9.4 | 0 |
| CVA | Ischemic – R parietotemporal – CT brain without contrast | 2 | VA ECMO | 10.2 | 0 |
| PE | CT Chest Angiogram Right interlobar and bilateral lower segment arterial branches | 9 | BIVAD | 7.0 | 0 |
| DVT | Doppler US – L Axillary Vein | 4 | Heart-Lung Transplant | 38.0 | 56.9 |
| DVT | Doppler US – LIJ, Subclavian Vein – associated pacemaker wires | 9 | AVR/MVR/TVR/ASD repair | 9.8 | 0 |
| DVT | Doppler US of RUE – RIJ associated central venous catheter | 6 | AVR/Aortic Root Repair/TAA/Hemiarch | 25.9 | 13.0 |
| DVT | Doppler US of RUE – RIJ/Subclavian – associated central venous catheter | 7 | TAAA Repair | 23.1 | 22.2 |
| DVT | Doppler US of LUE – L Subclavian/Axillary associated pacemaker wires | 8 | HM2 LVAD, TV/AV Repairs, and ASD Repair | 12.1 | 0 |
| DVT | Doppler US of LUE – L IJ – no associated structures | 6 | AVR/Aortic Root/TAA | 18.3 | 0 |
Abbreviations: ASD=Atrial septal defect; AVR=Aortic valve replacement; BiVAD=Biventricular assist device include both right ventricular assist device (RVAD) and Left VAD, RVAD cannula are inserted in the right atrium and pulmonary artery; LVAD cannula are inserted in the LV apex and ascending aorta. CABG=Coronary artery bypass graft; CVA=Cerebrovascular accident; HM2=Heartmate II LVAD ; Heart-Lung transplant=combine organ transplantation with en bloc recipient cardiectomy and bilateral pneumonectomies followed by en bloc implantation of donor heart and lungs. MVR=Mitral valve replacement; POD=Postoperative day; TAAA=Thoracoabdominal aortic; TAA=Thoracic aortic aneurysm; TVR=Tricuspid valve replacement; VA ECMO=Venoarterial Extracorporeal Membrane Oxygenation, inflow inserted within right atrium and outflow inserted within the ascending aorta.