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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Biochem Pharmacol. 2019 Apr 13;164:205–215. doi: 10.1016/j.bcp.2019.04.016

Figure 5. SUGEN causes irreversible pulmonary vascular remodeling via Akt suppression.

Figure 5.

(A) Representative images of Masson’s trichrome staining and (B) Bar graph of vessel thickness of lung sections from ECKOAkt1 mice subjected to hypoxia alone or SUGEN-hypoxia and WT mice subjected to SUGEN-hypoxia. (C-D) Representative Western blot images and (E-F) bar graphs of the band densitometry of HMECs treated with 10 μM SUGEN for 24 and 72 hours, respectively showing that SUGEN treatment directly inhibits Akt. One-way ANOVA was performed for figure B and Unpaired t-test was performed for figures C and D. Data are represented as mean ± SD. (n=3–5), *p<0.05; **p<0.01.