Table 1.
Characteristics of women according to personal history of benign breast disease (BBD)1 status in the Breast Cancer Prospective Family Study Cohort (ProF-SC)
| Characteristic at baseline | BBD (n = 4,704) | No BBD (n = 12,450) | p-value2 |
|---|---|---|---|
| Mean values (SD) | |||
| Age at baseline (years) | 49.80 (12.80) | 45.70 (15.80) | <0.0001 |
| Body mass index (kg/m2) | 25.70 (5.60) | 25.90 (5.70) | 0.07 |
| Age at menarche (years) | 12.80 (1.60) | 12.90 (1.60) | 0.001 |
| Age at first BBD diagnosis (years) | 37.9 (12) | NA | |
| Age at breast cancer diagnosis (years) | 57.40 (11.40) | 54.90 (12.70) | 0.002 |
| BOADICEA full-lifetime score (%) | 23.80 (16.20) | 23.30 (16.70) | <0.0001 |
| BOADICEA 1-year risk score (%) | 0.57 (0.70) | 0.43 (0.59) | <0.0001 |
| N (%) | |||
| BBD relative to pregnancy (in parous women) | |||
| BBD before first pregnancy | 585 (15.6) | NA | |
| BBD after first pregnancy | 3,177 (84.5) | NA | |
| Race/ethnicity | <0.0001 | ||
| Non-Hispanic white | 3,968 (84.4) | 9,772 (78.5) | |
| Non-Hispanic black | 163 (3.5) | 639 (5.1) | |
| Hispanic | 293 (6.2) | 1,129 (9.1) | |
| Asian | 123 (2.6) | 532 (4.3) | |
| Other | 148 (3.2) | 319 (2.6) | |
| Missing | 9 (0.2) | 59 (0.5) | |
| Education | 0.003 | ||
| High school graduate or less | 1,478 (31.4) | 4,225 (33.9) | |
| Some college/vocational school | 1,818 (38.7) | 4,720 (37.9) | |
| Bachelor’s/graduate degree | 1,393 (29.6) | 3,444 (27.7) | |
| Missing | 15 (0.3) | 61 (0.5) | |
| Parity (number of full-term pregnancies)/breastfeeding history | <0.0001 | ||
| Nulliparous | 808 (17.2) | 3,286 (26.4) | |
| Parous 1-2/no breastfeeding | 637 (13.5) | 1,372 (11.0) | |
| Parous 1-2/breastfed | 1,406 (29.9) | 3,205 (25.7) | |
| Parous 3+/no breastfeeding | 395 (8.4) | 988 (7.9) | |
| Parous 3+/breastfed | 1,444 (30.7) | 3,514 (28.2) | |
| Missing | 14 (0.3) | 85 (0.7) | |
| Hormonal birth control use | <0.0001 | ||
| Never | 1,024 (21.8) | 3,127 (25.1) | |
| Former | 3,296 (70.1) | 7,323 (58.8) | |
| Current | 370 (7.9) | 1,937 (15.6) | |
| Missing | 14 (0.3) | 63 (0.5) | |
| Menopausal status | |||
| Premenopausal | 2,132 (45.3) | 7,025 (56.4) | <0.0001 |
| Postmenopausal | 2,159 (45.9) | 4,726 (38.0) | |
| Missing | 413 (8.8) | 699 (5.6) | |
| Hormone therapy use | <0.0001 | ||
| Never | 3,141 (66.8) | 9,799 (78.7) | |
| Former | 710 (15.1) | 1,235 (9.9) | |
| Current | 754 (16.0) | 1,228 (9.9) | |
| Missing | 99 (2.1) | 188 (1.5) | |
| Cigarette smoking history3 | <0.0001 | ||
| Nonsmoker | 2,542 (54.0) | 7,419 (59.6) | |
| Former smoker | 1,345 (28.6) | 2,932 (23.6) | |
| Current smoker | 607 (12.9) | 1,712 (13.8) | |
| Missing | 210 (4.5) | 387 (3.1) | |
| Alcohol consumption4 | 0.002 | ||
| Non-regular drinker | 2,273 (48.3) | 6,372 (51.2) | |
| Former drinker | 711 (15.1) | 1,832 (14.7) | |
| Current drinker | 1,707 (36.3) | 4,189 (33.7) | |
| Missing | 13 (0.3) | 57 (0.5) | |
| Ever had a mammogram | <0.0001 | ||
| Yes | 4,334 (92.1) | 8,227 (66.1) | |
| No | 364 (7.7) | 4,200 (33.7) | |
| Missing | 6 (0.1) | 23 (0.2) | |
| BRCA1/2 mutation carriers | |||
| BRCA1/2 carrier | 302 (6.42) | 906 (7.28) | 0.05 |
| Noncarrier or not tested | 4,402 (93.58) | 11,544 (92.72) |
1
Women were classified as having BBD if they answered “yes” to the question:“Has a doctor ever told you that you had a benign breast disease, such as a noncancerous cyst or breast lump?.”
2
p-values from Wilcoxon–Mann–Whitney test, t-test, or χ2 test where appropriate.
3
Smokers are defined as having smoked at least one cigarette per day for 3 months or longer.
4
Regular drinkers are defined as consuming one alcoholic beverage at least once a week for 6 months or longer.