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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2019 Apr 12;1861(6):1180–1188. doi: 10.1016/j.bbamem.2019.04.006

Fig. 8.

Fig. 8.

Effect of depleting caffeine-sensitive stores on Ca2+ responses evoked by a 5 ns pulse. (A) Schematic diagram showing the order in which ryanodine and caffeine were applied to the cells. (B) Representative traces showing release of Ca2+ from the ER by caffeine in cells pretreated with ryanodine for 15 min. (C) Representative Ca2+ responses (n = 11) evoked by a 5 ns pulse (arrow) in cells treated with ryanodine and caffeine. (D) Averaged fluorescence traces ± s.e. (n = 14) showing the lack of effect of a 5 ns pulse (arrow) on [Ca2+]i in cells treated with ryanodine, caffeine and 2-APB (100 μM). Error bars not shown are within the thickness of the line.