. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: Biochim Biophys Acta Rev Cancer. 2019 Jan 29;1871(2):225–239. doi: 10.1016/j.bbcan.2019.01.004

Table 2:

PTMs identified on M₂PYK (or a MPYK isozyme without distinguishing between M₁PYK and M₂PYK)

PTM type	Amino Acid Residue Location if known	Ref
Glycosylation		[1, 2]
O-GlcNAc (Serine/threonine)	403 and 405	[3–6]
O-methylation (glutamic acid/aspartic acid)		[7]
Oxidation	358	[8]
Methylation (arginine)	445, 447 and 455	[9]
MARlation		[10]
N-acetylserine	2	Uniprot HPRD
N6-acetyllysine	3, 62, 89, 135, 162, 166, 206, 207, 230,266,305, 433 and 498	Uniprot HPRD PhosphoSitePlus [13–18]
Nitrosylation (cysteine)	49	HPRD
Nitrosylation (tryptophan)		[19]
Nitrosylation (tyrosine)		[20, 21]
Phosphorylation (serine/threonine)	37, 41, 45, 50, 57, 60, 77, 80, 87, 93, 95, 97, 100, 127, 129, 172, 195, 202, 222, 243, 249, 287, 328, 437 and 454	Uniprot HPRD PhosphoSitePlus [22–38]
Phosphorylation (tyrosine)	83, 105, 148, 149, 175, 370, 390 and 466	Uniprot HPRD PhosphoSitePlus [30, 39–45]
Sumolation		[94]
Succinylation (lysine)	62, 66, 115, 135, 247, 311, and 498	[95]
Ubiquitination (lysine)	66, 115, 125, 136, 141, 151, 166, 186, 188, 206 224, 261, 277, 311, 322, 336, 367, 475	PhosphoSitePlus [98, 99]
4-hydroxylation (prolines	403 and 408	Uniprot and [70]
Prolyl isomerization		[102, 103]