Skip to main content
. Author manuscript; available in PMC: 2020 May 16.
Published in final edited form as: Cell Chem Biol. 2019 Mar 7;26(5):724–736.e7. doi: 10.1016/j.chembiol.2019.02.004

Figure 5. Phylogenetic analysis of Spz15 adenylation protein.

Figure 5.

Phylogenetic tree of Spz15 with characterized adenylation domains and NCBI blastp homologs of Spz15 was constructed using Geneious software. Spz15 (marked with orange dot) forms a separate clade from canonical modular characterized adenylation domains (highlighted in blue). Proteins that clade with Spz15 (highlighted in orange) are found within putative phenazine type (phz) BGCs. The remaining protein sequences are discrete standalone adenylation enzymes. Protein abbreviations as follows: LnmQ – leinamycin, Pls – ε-poly-L-lysine, NRPS: BlmIXM7 – bleomycin module 7, SgvD4M6 – griseoviridin module 6, CymAM3 – cyclomarin module 3, LgrM2 – linear gramicidin module 2, MelGM7 – melithiazol module 7, Bat2M2 – batumin module 2, PedFM2 – pederin module 2, ClbJM7 – colibactin module 7, CucJM4 – cupriachelin module 4, TioRM2 – thiocoraline module 2, StenTM – stenothricin module 9, Sky31M9 – skyllamycin module 9, DptBCM10 – daptomycin module 10, Tar8M5 – taromycin module 5, CdaPS2M8 – calcium dependent antibiotic module 8, BaeJM2 – bacillaene module 2, AryDM3 – arylomycin module 3; all sequences were downloaded from NCBI protein database. See also Figures S6 and S7.