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. Author manuscript; available in PMC: 2020 Nov 10.
Published in final edited form as: Neuroscience. 2018 Nov 17;420:12–21. doi: 10.1016/j.neuroscience.2018.11.012

Figure 1: Functions of postsynaptic synaptobrevins.

Figure 1:

The model summarizes some of our current knowledge of the role of postsynaptic Sybs in regulating neurotransmitter receptor trafficking. Syb-2 has been suggested to be an integral part of GABAAR-containing vesicles and regulate basal insertion in dendritic membranes. Moreover, Syb-2 may be located at AMPAR-containing endosomes, thus participating in basal and activity-dependent exocytic events either induced by NMDAR activation or during synaptic scaling induced by retinoic acid, a type of homeostatic plasticity. In addition, Syb-1, another common isoform of Syb in the CNS, has been suggested to specifically regulate constitutive NMDAR exocytosis.