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. Author manuscript; available in PMC: 2020 Nov 10.
Published in final edited form as: Neuroscience. 2018 Nov 17;420:12–21. doi: 10.1016/j.neuroscience.2018.11.012

Figure 2: Functions of postsynaptic syntaxins.

Figure 2:

The model represents the role of different postsynaptic syntaxins in regulating neurotransmitter receptor dynamics. Despite being mostly concentrated at presynaptic terminals, Stx-1 has been suggested to play a role in regulating constitutive exocytosis of GABAARs, AMPARs and GluN2B-containing NMDA receptors. Interestingly, GluN2A-containing NMDARs insertion may depend on Stx-4, a non-complexin Stx isoform that also mediates AMPAR exocytosis during homeostatic plasticity. In contrast Stx-3, a complexin-binding isoform is the primary regulator of AMPAR exocytosis during NMDAR-dependent LTP. These results suggest dendritic membranes may contain microdomains enriched with different Stx isoforms which define specific regions for postsynaptic receptor exocytosis.