Table 2.
Performance of top models for each number of microbiome markers.
Number of microbiome markers | Model string | AIC | Training | Validation | AUC in testing | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Sensitivity | Specificity | Accuracy | AUC | Sensitivity | Specificity | Accuracy | AUC | ||||
10 | class~age + sex + g778 + g362 + g319 + g769 + g147 + g725 + g348 + g837 + g732 + g179 | 208.8 | 0.845 | 0.865 | 0.859 | 0.923 | 0.727 | 0.834 | 0.804 | 0.860 | 0.893 |
9 | class~age + sex + g778 + g362 + g319 + g147 + g725 + g348 + g837 + g732 + g179 | 207.1 | 0.844 | 0.856 | 0.853 | 0.920 | 0.750 | 0.838 | 0.813 | 0.873 | 0.892 |
8 | class~age + sex + g778 + g362 + g319 + g147 + g725 + g837 + g732 + g179 | 206.4 | 0.844 | 0.859 | 0.855 | 0.921 | 0.748 | 0.836 | 0.811 | 0.865 | 0.887 |
7 | class~age + sex + g778 + g362 + g319 + g147 + g725 + g837 + g732 | 205.9 | 0.814 | 0.856 | 0.844 | 0.914 | 0.759 | 0.861 | 0.832 | 0.886 | 0.885 |
6 | class~age + sex + g778 + g362 + g319 + g147 + g837 + g732 | 205.3 | 0.808 | 0.863 | 0.848 | 0.916 | 0.746 | 0.833 | 0.808 | 0.870 | 0.887 |
5* | class~age + sex + g778 + g362 + g319 + g147 + g732 | 205.1 | 0.797 | 0.871 | 0.850 | 0.908 | 0.729 | 0.850 | 0.816 | 0.879 | 0.875 |
4 | class~age + sex + g362 + g319 + g147 + g732 | 206.3 | 0.783 | 0.855 | 0.835 | 0.904 | 0.746 | 0.836 | 0.811 | 0.872 | 0.875 |
3 | class~age + sex + g362 + g147 + g732 | 211.9 | 0.804 | 0.830 | 0.823 | 0.901 | 0.757 | 0.829 | 0.809 | 0.877 | 0.850 |
2 | class~age + sex + g362 + g732 | 221.6 | 0.790 | 0.823 | 0.814 | 0.888 | 0.761 | 0.790 | 0.781 | 0.864 | 0.820 |
1 | class~age + sex + g319 | 257.5 | 0.624 | 0.835 | 0.775 | 0.795 | 0.597 | 0.822 | 0.759 | 0.776 | 0.767 |
0 | class~age + sex | 321.6 | 0.633 | 0.572 | 0.589 | 0.660 | 0.637 | 0.571 | 0.590 | 0.650 | 0.562 |
*The finally selected model showing the lowest AIC.
**The OTU symbols are as following: g778, Pseudomonas; g362, Streptococcus; g319, Staphylococcus; g769, Acinetobacter; g147, Bifidobacterium; g725, Klebsiella; g348, Enterococcus; g837, Akkermansia; g732, Trabulsiella; g179, Prevotella.