Table 2.

Change from baseline to week 12 in red blood cell membrane concentrations of key fatty acids

RBC membrane fatty acida	IPE 4 g/day			Placebo			Change from baseline, IPE 4 g/day vs placebo, %, P
Concentration, μg/g	Baseline (SD)	Week 12 (SD)	Change (SE)	Baseline (SD)	Week 12 (SD)	Change (SE)
EPA (C20:5n-3)	6.09	43.28	39.38	7.09	6.40	0.84	618.46
n = 49, 48	(2.248)	(17.957)	(1.791)	(3.320)	(3.313)	(1.730)	< 0.0001
DHA (C22:6n-3)	44.10	39.14	− 6.29	47.35	45.12	− 2.70	− 6.12
n = 44, 47	(11.708)	(8.328)	(0.983)	(11.696)	(11.861)	(0.919)	0.0178
DPA (C22:5n-3)	28.54	62.14	33.67	29.69	28.60	− 0.85	123.56
n = 46, 46	(5.757)	(12.564)	(1.417)	(5.496)	(5.146)	(1.380)	< 0.0001
Palmitic (C16:0)	304.13	301.24	− 5.77	313.71	313.52	0.04	− 2.24
n = 46, 50	(36.930)	(36.607)	(4.438)	(39.421)	(32.643)	(4.151)	0.1895
Stearic (C18:0)	170.95	170.73	− 1.15	173.93	174.73	0.74	− 0.71
n = 45, 46	(18.926)	(18.752)	(2.550)	(15.024)	(18.323)	(2.466)	0.7048
Oleic (C18:1n-9)	194.52	188.77	− 7.74	198.70	198.42	− 1.00	− 3.15
n = 45, 45	(27.259)	(23.798)	(3.060)	(24.650)	(24.609)	(2.997)	0.0943
Linoleic (C18:2n-6)	146.81	132.49	− 15.77	151.38	153.50	1.53	− 10.65
n = 48, 48	(31.853)	(26.003)	(3.752)	(24.241)	(32.521)	(3.612)	0.0004
AA (C20:4n-6)	185.38	153.50	− 37.08	189.44	193.57	0.98	− 19.48
n = 44, 47	(37.044)	(28.599)	(3.596)	(25.769)	(27.707)	(3.417)	< 0.0001
AA/EPA	31.86	3.61	− 26.95	31.44	33.26	3.10	− 98.64
n = 46, 50	(10.373)	(1.700)	(0.801)	(11.465)	(9.955)	(0.767)	<0.0001

^aPatient numbers (n) are reported for IPE 4 g/day and placebo, respectively

Mean and SD are reported for baseline and end-of-treatment values; least squares mean and SE are reported for changes from baseline; least squares mean is reported for percent changes from baseline vs. placebo

AA arachidonic acid, DHA docosahexaenoic acid, DPA docosapentaenoic acid, EPA eicosapentaenoic acid, IPE icosapent ethyl, RBC red blood cell, SD standard deviation, SE standard error