Table 2.
The effect of regular exercise on circulating microRNAs related to cardiovascular disease.
| miRNA | n | Fold-Change (SD) | P value a | q value b |
|---|---|---|---|---|
| miR-486-5p | 20 | 0.65 (0.4) | 0.0002 | 0.0009 |
| let-7b-5p | 20 | 0.64 (0.5) | 0.0003 | 0.0019 |
| miR-142-3p | 19 | 3.60 (3.8) | 0.001 | 0.0028 |
| miR-221-3p | 19 | 2.70 (2.6) | 0.0015 | 0.0038 |
| miR-29c-3p | 20 | 0.77 (0.3) | 0.0015 | 0.0047 |
| miR-126-3p | 20 | 1.41 (0.5) | 0.0025 | 0.0057 |
| let-7e-5p | 18 | 0.65 (0.4) | 0.004 | 0.0066 |
| miR-93-5p | 18 | 0.73 (0.5) | 0.0049 | 0.0075 |
| miR-7-5p | 16 | 0.75 (1.3) | 0.0052 | 0.0085 |
| miR-146a-5p | 20 | 1.55 (0.8) | 0.0053 | 0.0094 |
| miR-25-3p | 20 | 0.78 (0.4) | 0.0053 | 0.0104 |
| miR-27b-3p | 20 | 1.97 (1.2) | 0.0062 | 0.0113 |
| miR-92a-3p | 20 | 0.83 (0.4) | 0.0098 | 0.0123 |
| miR-29b-3p | 16 | 0.79 (0.4) | 0.0131 | 0.0132 |
| let-7d-5p | 20 | 0.84 (0.4) | 0.0175 | 0.0142 |
| miR-17-5p | 16 | 2.04 (1.7) | 0.0208 | 0.0151 |
| miR-424-5p | 19 | 1.85 (1.5) | 0.0439 | 0.016 |
| miR-23a-3p | 20 | 1.35 (0.6) | 0.0477 | 0.017 |
| miR-222-3p | 18 | 1.36 (0.6) | 0.0483 | 0.0179 |
| miR-30c-5p | 20 | 1.62 (0.9) | 0.0579 | 0.0189 |
| miR-27a-3p | 20 | 2.04 (1.6) | 0.0613 | 0.0198 |
| miR-103a-3p | 13 | 7.42 (12.3) | 0.079 | 0.0208 |
| let-7a-5p | 20 | 1.06 (1.1) | 0.0875 | 0.0217 |
| miR-29a-3p | 20 | 1.50 (1.0) | 0.0907 | 0.0226 |
| miR-24-3p | 20 | 1.47 (0.7) | 0.0917 | 0.0236 |
| miR-125a-5p | 20 | 1.46 (0.9) | 0.1006 | 0.0245 |
| miR-16-5p | 20 | 1.01 (1.0) | 0.1025 | 0.0255 |
| let-7c | 20 | 1.11 (1.2) | 0.1324 | 0.0264 |
| miR-342-3p | 20 | 1.47 (1.0) | 0.1514 | 0.0274 |
| miR-15b-5p | 20 | 0.95 (0.4) | 0.1564 | 0.0283 |
| miR-181b-5p | 14 | 1.67 (1.4) | 0.2046 | 0.0292 |
| miR-224-5p | 10 | 2.37 (2.2) | 0.2192 | 0.0302 |
| miR-125b-5p | 15 | 2.57 (2.9) | 0.2577 | 0.0311 |
| miR-130a-3p | 11 | 2.20 (1.7) | 0.3041 | 0.0321 |
| miR-195-5p | 20 | 1.48 (2.5) | 0.3096 | 0.033 |
| miR-185-5p | 18 | 1.60 (2.1) | 0.3166 | 0.034 |
| miR-10b-5p | 14 | 3.42 (4.3) | 0.3411 | 0.0349 |
| miR-150-5p | 20 | 1.40 (0.8) | 0.3693 | 0.0358 |
| miR-23b-3p | 19 | 1.34 (0.6) | 0.4056 | 0.0368 |
| miR-223-3p | 20 | 1.37 (1.3) | 0.4779 | 0.0377 |
| miR-320a | 20 | 1.13 (1.0) | 0.5106 | 0.0387 |
| miR-30e-5p | 18 | 1.72 (2.1) | 0.6095 | 0.0396 |
| miR-423-3p | 13 | 2.21 (2.3) | 0.6245 | 0.0406 |
| miR-98-5p | 18 | 1.31 (0.9) | 0.6554 | 0.0415 |
| miR-26a-5p | 20 | 1.11 (0.5) | 0.7655 | 0.0425 |
| miR-122-5p | 20 | 1.41 (1.4) | 0.7881 | 0.0434 |
| miR-26b-5p | 19 | 3.97 (13.1) | 0.82 | 0.0443 |
| miR-451a | 20 | 1.89 (2.9) | 0.8475 | 0.0453 |
| miR-100-5p | 19 | 1.59 (1.6) | 0.8936 | 0.0462 |
| miR-30d-5p | 20 | 1.30 (1.1) | 0.9146 | 0.0472 |
| miR-30a-5p | 20 | 1.31 (1.0) | 0.9536 | 0.0481 |
| miR-21-5p | 20 | 1.06 (0.4) | 0.9546 | 0.0491 |
| miR-365a-3p | 15 | 1.65 (1.8) | 0.9907 | 0.05 |
n represents the number of subjects in which the miRNA was detectable in both baseline and post-training samples.
aP values are the result of paired t-tests of normalized baseline and post-training miRNA expression levels.
bWhen P < q the change in expression with training is deemed significant, which is indicated in bold.