Table 2.
Associations between six HSP expression and clinicopathological features of breast cancer patients.
| Characteristic | No. of total cases | HSPA2 expression | DNAJC20 expression | HSP90AA1 expression | CCT1 expression | CCT2 expression | CCT6A expression | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| mean | p-value | mean | p-value | mean | p-value | mean | p-value | mean | p-value | mean | p-value | ||
| Clinical stage | |||||||||||||
| I | 124 | 1,78 | 0,1453 | 0,42 | 0,583 | 1,55 | < 0,0001**** | 0,51 | 0,0277* | 1,06 | 0,0005*** | 0,89 | 0,0185* |
| II | 358 | 1,45 | 0,37 | 1,82 | 0,66 | 1,17 | 1,05 | ||||||
| III & IV | 130 | 1,61 | 0,35 | 1,95 | 0,69 | 1,33 | 1,03 | ||||||
| Tumor | |||||||||||||
| T1 | 210 | 1,78 | 0,0162* | 0,40 | 0,4798 | 1,61 | < 0,0001**** | 0,49 | < 0,0001**** | 1,06 | 0,0003*** | 0,86 | < 0,0001**** |
| T2 | 469 | 1,39 | 0,36 | 1,87 | 0,71 | 1,25 | 1,09 | ||||||
| T3 & T4 | 109 | 1,43 | 0,41 | 1,86 | 0,68 | 1,26 | 1,01 | ||||||
| Nodes | |||||||||||||
| N0 & N1 | 649 | 1,52 | 0,6461 | 0,40 | 0,0828 | 1,77 | 0,0139* | 0,64 | 0,3534 | 1,17 | 0,0030** | 1,02 | 0,4735 |
| N2 & N3 | 142 | 1,45 | 0,30 | 1,92 | 0,69 | 1,34 | 1,05 | ||||||
| Metastasis | |||||||||||||
| M0 | 771 | 1,49 | 0,1767 | 0,38 | 0,5855 | 1,80 | 0,6848 | 0,65 | 0,7587 | 1,21 | 0,4929 | 1,02 | 0,5778 |
| M1 | 14 | 2,09 | 0,29 | 1,73 | 0,70 | 1,10 | 0,94 | ||||||
| ER | |||||||||||||
| positive | 601 | 1,78 | < 0,0001**** | 0,42 | 0,0198* | 1,73 | 0,0015** | 0,52 | < 0,0001**** | 1,21 | 0,2401 | 0,90 | < 0,0001**** |
| negative | 179 | 0,66 | 0,30 | 1,91 | 1,04 | 1,15 | 1,42 | ||||||
| PR | |||||||||||||
| positive | 522 | 1,86 | < 0,0001**** | 0,42 | 0,0641 | 1,71 | < 0,0001**** | 0,50 | < 0,0001**** | 1,20 | 0,942 | 0,88 | < 0,0001**** |
| negative | 255 | 0,83 | 0,33 | 1,92 | 0,92 | 1,21 | 1,29 | ||||||
| HER2 | |||||||||||||
| positive | 114 | 1,45 | 0,6285 | 0,58 | 0,0001**** | 2,11 | < 0,0001**** | 0,87 | < 0,0001**** | 1,37 | 0,0002*** | 1,15 | 0,0075** |
| negative | 652 | 1,54 | 0,35 | 1,73 | 0,61 | 1,16 | 1,00 | ||||||
Expression of individual HSP was compared between cohorts stratified by clinicopathological features using unpaired t test (for two groups) or one-way ANOVA (for three groups). n.s. = not significant (P > 0,05); *P ≤ 0,05; **P ≤ 0,01; ***P ≤ 0,001; ****p ≤ 0,0001. Data for TCGA BRCA patients were obtained from XENA browser.