Table 1.
IC50 for BYL719, either alone or in combination, in TNBC15.
| Cell line | Subtype | RB status | Mutations | Single Agent | Combination BYL719 + LEE011 | ||
|---|---|---|---|---|---|---|---|
| BYL719 IC50 (μM) | LEE011 IC50 (μM) | BYL719 IC50 (μM) | IC50 Fold Reduction | ||||
| HCC38 | BL1 | WT | CDKN2A; TP53 | 26.01 | >40 | 11.88 | 2.19 |
| MDA-MB-468 | BL1 | Mut | PTEN;SMAD4;TP53 | 11.28 | >40 | 13.46 | 0.84 |
| HCC1806 | BL2 | WT | CDKN2A;TP53;UTX | 8.18 | >40 | 5.75 | 1.42 |
| HCC1187 | IM | WT | TP53;CTNNA1;DDX18;HUWE1;NFKBIA | 14.41 | >10 | 11.04 | 1.30 |
| BT549 | M | Mut | PTEN;TP53 | 17.37 | >40 | 14.61 | 1.19 |
| Hs578T | MSL | WT | CDKN2A;TP53 | 19.84 | >40 | 8.99 | 2.21 |
| MDA-MB-231 | MSL | WT | BRAF;CDKN2A;KRAS;NF2;TP53;PDGFRA | 19.29 | 13.01 | 6.80 | 2.83 |
| MFM223 | LAR | WT | PIK3CA;TP53 | 3.68 | >20 | 0.79 | 4.66 |
| T47D | ER+/PR+/HER2+ | WT | PIK3CA;TP53 | 0.26 | 25.24 | ||