Figure 2.

Recurrent Perturbation-Transcript Regulatory Relationships

(A) Summary of the recurrent relationships between the chemical and genetic perturbations and the regulated transcripts. The upper panels show the number of significant relationships per perturbation, whereas the lower panels show the same per gene. d6, small-molecule or drug treatment for 6 h; d24, small-molecule or drug treatment for 24 h; sh96, short hairpin RNA treatment for 96 h. REC, recurrence score.

(B) Comparison between d6 and d24 recurrent relationships. FDR, false discovery rate.

(C) On-target sh96 recurrent relationships. The REC scores for significant on-target pairs are shown in a violin plot; line, median.

(D) Top 10 significant d6, d24, and sh96 recurrent pairs.