Candidate orthologous groups (OGs) with CAFE overall p values < 0.01 for which a model favoring selection for larger sizes in Polyphaga showed a greater likelihood. OG identifiers for functional category cytochrome P450s (P450), carboxylesterases (CE), glutathione S-transferases (GST), and cysteine proteases (CYS) are from OrthoDB v8 (ODB8 ID). Akaike Information Criterion corrected for small sample size (AICc) values are reported for all tested models. BM1 (Brownian motion with a single rate for the whole tree), BMS (Brownian motion with different rates for each regime), OU1 (selection towards the same optimum for both regimes) all represent the null hypothesis. OUM (selection towards two optima, same variance) and OUMV (selection towards two optima, two variances) represent the alternative hypotheses. The mean values in each suborder (Adephaga vs. Polyphaga) are presented in the last two columns. Values in italics indicate the preferred (maximum likelihood) model. A delta AICc > 2 is required for H1 to be retained