Table 2.
Multivariable Cox regression analysis of 30-day mortality after ICU admission according to positive and negative fluctuations in Cl− levels within 72 h after ICU admission
| Variables | Multivariable model | P |
|---|---|---|
| Hazard ratio (95% CI) | ||
| Model 1 | ||
| aPositive fluctuation in Cl− (1 mmol L− 1 increase) | 1.08 (1.04, 1.11) | < 0.001 |
| bNegative fluctuation in Cl− (1 mmol L− 1 increase) | 1.03 (0.98, 1.08) | 0.313 |
| Cumulative FB groupc | ||
| Even (0–5%) | 1 | (< 0.001) |
| Negative (< 0%) | 0.97 (0.72, 1.32) | 0.868 |
| Positive, Mild to moderate (5–10%) | 2.01 (1.57, 2.57) | < 0.001 |
| Positive, Severe (> 10%) | 4.06 (3.10, 5.32) | < 0.001 |
| Dyschloremia at ICU admission | ||
| Normochloremia (97–110 mmol L− 1) | 1 | (< 0.001) |
| Hypochloremia (< 97 mmol L− 1) | 1.99 (1.57, 2.51) | < 0.001 |
| Hyperchloremia (> 110 mmol L− 1) | 0.78 (0.60, 1.00) | 0.054 |
| Model 2 | ||
| aPositive fluctuation of Cl− > 10 mmol L− 1 | 3.37 (2.01, 5.67) | < 0.001 |
| bNegative fluctuation of Cl− > 10 mmol L− 1 | 0.94 (0.38, 2.30) | 0.883 |
ICU intensive care unit, FB fluid balance
aPositive fluctuation in Cl−: (Maximum Cl− – Preadmission Cl−) for 72 h after ICU admission
bNegative fluctuation in Cl−: (Preadmission Cl− – Minimum Cl−) for 72 h after ICU admission
cCumulative fluid balance (%): (Total input fluid – total output fluid, L) × 100 x weight at admission (kg)− 1