Table 3.

Comparison of baseline and yearly change of health status between subjects with or without at least one acute exacerbation during the follow up, among those with airflow obstruction

	Exacerbation(s) during follow up	No exacerbation during follow up	p
	(n = 25)	(n = 36)
Baseline
SF36 PCS (sum score)	76.4 [65.1–82]	76 [64.6–81.3]	0.92
SF36 MCS (sum score)	79.5 [72.5–84.3]	80.1 [74.0–85.8]	0.79
EQ-5D index (score)	0.76 [0.74–1]	0.77 [0.76–1.00]	0.70
EQ-5D VAS (score)	75 [70–80]	80 [70–85]	0.48
CCQ (total score)	1.2 [0.3–1.5]	0.70 [0.40–1.00]	0.22
CAT (score)a	10.5 [6–17.5]	8 [5–13]	0.11
Yearly change
SF36 PCS (sum score)	−1.51 (0.47)	−0.50 (0.53)	0.16
SF36 MCS (sum score)	−1.22 (0.54)	0.03 (0.45)	0.16
EQ-5D index (score)	−0.022 (0.010)	−0.015 (0.012)	0.66
EQ-5D VAS (score)	−0.82 (0.47)	− 0.40 (0.35)	0.48
CCQ (total score)	0.068 (0.025)	0.042 (0.028)	0.63
CAT (score)	0.91 (0.21)	−0.26 (0.25)	< 0.01

Data are expressed as median [interquartile range] or average (SE). Baseline data were compared with a Mann–Whitney test, yearly change with a mixed model. SF36 = Short form 36 health survey, PCS = physical component summary, MCS = mental component summary, EQ-5D = Generic EuroQol 5 dimensions, VAS = visual analog scale, CCQ = Clinical COPD Questionnaire, CAT = COPD assessment test (^a= data from the third year visit). Missing values: Had acute exacerbation(s) – EQ-5D index and CAT n = 1, CCQ n = 3, in both baseline and yearly change. Did not have acute exacerbation – Baseline: SF36 n = 1, EQ-5D index and CCQ n = 3, EQ-5D VAS n = 2, CAT n = 13. Yearly change: SF36 and EQ-5D index n = 7, EQ-5D VAS n = 8, CCQ n = 9, CAT n = 12