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. 2019 May 17;19:465. doi: 10.1186/s12885-019-5698-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Diagnostic odds ratio (DOR), Deek’s funnel plot and Fagan’s Nomogram of cfDNA for SNV (ABC): a. The DOR of SNV was 40 (21–75) indicating high diagnostic performance; b. The p value was 0.70 (> 0.05) which suggests that there was no evidence of publication bias for SNV. c. The post-test probability of positive result was raised from 30 to 80%, which indicates a high diagnosis utility of cfDNA for detection of SNV