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. 2019 May 17;16:103. doi: 10.1186/s12974-019-1495-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — HDAC3 inhibition reduces hyperglycemia-IL1β (HG-IL1β) insult-induced permeability of cultured HBMEC monolayer. a Representative Western blot gel images of IL-1β expression in the mouse brain hippocampus and cortex tissues. b Quantification of Western blot analysis of IL-1β protein expression. Data are expressed as mean ± SEM. *P < 0.05 vs. db/+, n = 4; c. Relative HBMEC monolayer permeability after HG-IL1β insult with/without RGFP966 treatment. d TEER measurement of HBMEC monolayers after HG-IL1β insult with/without RGFP966 treatment. e Viability of cultured HBMEC after HG-IL1β insult with/without RGFP966 treatment. Data are expressed as mean ± SEM. *P < 0.05 vs. norm, ^#P < 0.05 vs. HG-IL1β, n = 6