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. 2019 May 17;20:386. doi: 10.1186/s12864-019-5773-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Developmental defects of Gam1-injected embryos. a Control (left) and Gam1-injected (right) late gastrula stage embryos showing delayed closure of the blastopore (arrow) in the latter. b Stage 35 (50 hpf) control embryo (left), Gam1 embryo with shortened A–P axis (center), Gam1 embryo with an open neural tube and edema around the heart (right). c An example of an eye defect (cyclopia). d Failure of the heart tube to initiate looping. (Left) A control embryo (96 hpf) in which the two atria (red) and ventricle (black) have fully developed compared to (right) a Gam1 embryo in which the heart tube has failed to undergo looping