Fig. 5.

BI 749327 reduces hypertrophic and profibrotic gene expression and myocardial fibrosis. (A) mRNA for hypertrophic marker genes are up-regulated in vehicle-treated TAC and reduced by BI 749327. S, sham; T, TAC. Sham data are not significantly different between groups. (B) mRNA for fibrosis-related genes in same myocardium. Elevation with TAC was suppressed by active drug therapy. (C, Left) Representative myocardial histology image at 20× magnification shows increased interstitial fibrosis in TAC-VEH that is suppressed by drug treatment. (C, Right) Summary data (*P < 0.0001; otherwise, P value noted on graph. Mann–Whitney test in drug treatment groups, no differences were present between shams. n = 6 per sham group, n = 12 TAC-VEH group, n = 15 TAC-BI 749327 group).