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. 2019 Apr 26;116(20):9941–9946. doi: 10.1073/pnas.1901183116

Fig. 5.

Fig. 5.

Model of PARP-1 dual binding to chromatin. (A) Full-length PARP-1 has two chromatin-binding regions: N-terminal ZI and ZII bind to DNA nonspecifically, allowing PARP-1 to scan chromatin by “walking” along DNA and the C-terminal domain which recognizes and binds to the H2Av-bearing nucleosome specifically. (B) The C-terminal domain recognizes specific epitopes of the H2Av-bearing nucleosome. (C) The ZI-ZII deletional isoform binds to DNA nonspecifically and does not interact with the nucleosome.