Table 1.
Roles of KLF in stem cell self‐renewal
| KLF proteins | Host organism | Tissue/cell analyzed | Key functionality | Genes regulated by KLFs |
|---|---|---|---|---|
| KLF1 | Mouse | Embryo 7 | Required for erythropoiesis 7 | Myc 7 |
| KLF2 | Mouse | Embryo and embryonic stem cells 1, 2, 7 | Promotes self‐renewal and pluripotency 1, 2
Required for erythropoiesis 7 |
Nanog and Esrrb
1, 2
Myc 1, 7 Oct4, Tcl1, Nr5a2, Tbx3, Rif1, Sox2, Tcf3, Mycn, and Foxd3 1 Stella 2 |
| Human | Bone marrow stromal cells 3 | Promotes self‐renewal and pluripotency 3 | Oct4, Nanog, and Rex1 3 | |
| Zebrafish | Embryo 6 | Required for embryogenesis 6 | Oct4 6 | |
| KLF4 | Mouse | Embryonic stem cells 1, 2 | Promotes self‐renewal and pluripotency 1, 2 |
Nanog and Esrrb
1, 2
Tcl1, Myc, Nr5a2, Tbx3, Nanog, Esrrb, Rif1, Oct4, Sox2, Tcf3, Mycn, and Foxd3 1 Stella 2 |
| Hematopoietic cells 4 | Promotes self‐renewal 4 | |||
| KLF5 | Mouse | Embryonic stem cells 1, 2, 5 | Promotes self‐renewal and pluripotency 1, 2, 5 |
Nanog
1, 2, 5
Esrrb 1, 2 Oct4 and Sox2 1, 5 Tcl1, Myc, Nr5a2, Tbx3, Esrrb, Rif1, Oct4, Tcf3, Mycn, and Foxd3 1 Stella 2 |
| KLF17 | Zebrafish | Embryo 6 | Required for embryogenesis 6 | Oct4 6 |
Abbreviation: KLF, Krüppel‐like factor.