Table 3.

OR with 95% CI of developing ACPA-positive and ACPA-negative RA for overweight and obese women compared with normal weight women stratified by smoking habits

	ACPA-positive RA		ACPA-negative RA
BMI	Ca/Co*	Ca/Co*	Ca/Co*	OR (95% CI)†
Never smokers
Normal weight	327/1089	1.0 (reference)	186/1089	1.0 (reference)
Overweight	156/541	1.0 (0.8–1.3)	98/541	1.1 (0.8–1.4)
Obesity	71/268	1.0 (0.7–1.3)	55/268	1.3 (0.9–1.8)
P for trend		0.8		0.8
Ever-smokers
Normal weight	617/1337	1.0 (reference)	257/1337	1.0 (reference)
Overweight	350/655	1.2 (1.0–1.4)	163/655	1.3 (1.0–1.6)
Obesity	171/232	1.6 (1.3–2.0)	96/232	2.1 (1.6–2.8)
P for trend		<0.0001		<0.0001

*Number of exposed cases and controls.

†Adjusted for age, gender, residential area, ancestry and study.

ACPA, anticitrullinated peptide antibody; BMI, body mass index; RA, rheumatoid arthritis.