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. 2019 May 10;5(1):e000898. doi: 10.1136/rmdopen-2019-000898

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Design for the long-term extension study RA-BEYOND from randomisation in the originating studies. Data are up to 2 years on treatment, corresponding to 100 weeks in RA-BEGIN and RA-BEAM or 96 weeks in RA-BUILD due to the different duration and visit structures of the originating studies. Patients from RA-BEGIN switched to baricitinib 4 mg at entry to RA-BEYOND at week 52; during RA-BEYOND, MTX or other csDMARDs could be prescribed at any time point at the discretion of the investigators. Patients from RA-BEAM originally randomised to placebo were switched to baricitinib 4 mg at rescue or week 24; patients randomised to adalimumab were switched to baricitinib 4 mg at rescue or entry to RA-BEYOND at week 52. Patients in RA-BUILD initially randomised to placebo switched to baricitinib 4 mg at rescue or week 24 at entry to RA-BEYOND. Patients who remained on baricitinib 2 mg in RA-BUILD continued on 2 mg in RA-BEYOND; those rescued from baricitinib 2 mg to 4 mg in RA-BUILD received baricitinib 4 mg in RA-BEYOND. Background csDMARDs were permitted in RA-BUILD and RA-BEAM. csDMARD, conventional synthetic DMARD; DMARD, disease-modifying antirheumatic drug; IR, inadequate responder; MTX, methotrexate; N, number of patients randomised and treated; Q2W, once every 2 weeks; QD, once daily; RA, rheumatoid arthritis.