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. 2019 May 10;5(1):e000898. doi: 10.1136/rmdopen-2019-000898

Figure 3.

Figure 3

Inhibition of radiographic progression of structural joint damage at year 1 and year 2 by original randomisation. The LS mean change from baseline (±SEM) in structural joint damage evaluated using (A) mTSS, (B) ES and (C) JSN for patients in RA-BEYOND originally completing RA-BEGIN, RA-BEAM or RA-BUILD. Time points represent time from randomisation in the originating studies. Indicated treatment groups are according to randomisation in the originating study (‘initial’ denotes initial randomised treatment group). Patients on PBO, MTX or ADA in the originating studies switched to baricitinib 4 mg at rescue or at 24 weeks (PBO; single arrow) or 52 weeks (MTX and ADA; double arrow) as detailed in the Study design section. Tables represent the number of patients for whom data were available for each time point and study. Comparisons were analysed using a mixed model for repeated measures. Missing scores at 2 years were imputed using linear extrapolation based on data collected between 1 and 2 years. SE of the mean *p≤0.05, **p≤0.01, ***p≤0.001 baricitinib 4 mg vs PBO (RA-BEAM; RA-BUILD) or MTX (RA-BEGIN); +p≤0.05, ++p≤0.01, +++p≤0.001 ADA vs PBO (RA-BEAM); ‡p≤0.05 baricitinib 4 mg vs baricitinib 4 mg plus MTX (RA-BEGIN). ADA, adalimumab; Bari, baricitinib; ES, erosion score; JSN, joint space narrowing; LS, least squares; mTSS, modified Total Sharp Score; MTX, methotrexate; PBO, placebo; RA, rheumatoid arthritis.