Table 2.
Fold up-regulation of gene expression in macrophages from WT, NOD2-KO and RIP2-KO mice after 6 h-stimulation with heat-killed Aa compared with WT untreated control.
| Gene name | WT | NOD2-KO | RIP2-KO |
|---|---|---|---|
| Ccl2 | 4.05 | 6.39 | |
| Cd14 | 4.00 | ||
| Clec4e | 4.73 | 5.54 | |
| Csf2 | 6.64 | 7.78 | |
| Csf3 | 16.64 | 28.12 | 12.41 |
| Cxcl10 | 13.91 | 15.36 | 39.12 |
| Ifnb1 | 11.87 | 9.50 | 12.14 |
| Ifng | 5.69 | 7.89 | |
| Il10 | 12.36 | 26.95 | 24.99 |
| Il12a | 15.14 | 4.34 | |
| Il1a | 83.56 | 12.67 | 16.38 |
| Il1b | 45.77 | 9.48 | 13.71 |
| Il6 | 16.56 | 8.95 | 14.20 |
| Myd88 | 1243.42 | ||
| Nfkb2 | 4.94 | ||
| Nfkbia | 7.93 | 4.07 | 5.32 |
| Nfkbib | 4.31 | ||
| Ptgs2 | 17.86 | 7.64 | 7.37 |
| Tlr2 | 7.50 | ||
| Tnf | 29.52 | 15.61 | 10.79 |
| Tnfaip3 | 8.23 | 4.05 | |
| Tlr3 | 4.21 | ||
| Tlr9 | 4.25 |