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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Schizophr Res. 2018 Dec 21;206:82–88. doi: 10.1016/j.schres.2018.12.010

Table 3.

The Association between APOE- ε4 and Symptoms in Schizophrenia

β p-value
Baseline Associations
 Reality Distortion (Hallucinations/Delusions) −0.08 0.73
 Disorganization 0.01 0.95
 Avolition/Apathy 0.06 0.78
 Inexpressivity 0.07 0.74
Longitudinal Associations
 Reality Distortion (Hallucinations/Delusions)
  APOE-ε4 0.22 0.12
  APOE-ε4 x Slope (prior to age 40) −0.10 0.46
  APOE-ε4 x Slope (post age 40) 0.52 < 0.0001
 Disorganization
  APOE-ε4 0.15 0.43
  APOE-ε4 x Slope (prior to age 40) −0.04 0.81
  APOE-ε4 x Slope (post age 40) 0.11 0.34
 Avolition/Apathy
  APOE-ε4 0.02 0.76
  APOE-ε4 x Slope (prior to age 50) −0.24 0.10
  APOE-ε4 x Slope (post age 50) 0.07 0.09
 Inexpressivity
  APOE-ε4 −0.06 0.92
  APOE-ε4 x Slope (prior to age 25) −0.24 0.08
  APOE-ε4 x Slope (post age 25) −0.20 0.49

Note. Analyses controlled for use of antipsychotics (time-varying covariate) and the first 10 principal components of genetic covariance. Baseline analyses were also controlled for age.